Mechanisms of Myocardial Ischemia

Pathophysiology of Ischemia/Reperfusion-induced Myocardial Injury: What We Have Learned From Preconditioning and Postconditioning?

Organ damage after reperfusion of previously viable ischemic tissues is defined as ischemia/reperfusion injury. The pathophysiology of ischemia/reperfusion injury involves cellular effect of ischemia, reactive oxygen species and inflammatory cascade. Protection against ischemia/reperfusion injury may be achieved by preconditioning or postconditioning. In this review, we discuss basic mechan...

Effect of losartan on NOX2 transcription following acute myocardial ischemia-reperfusion

Introduction: Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-2 (Nox2) is one of the predominant sources of ROS production during myocardial ischemia-reperfusion and can be induced by angiotensin II. The evidence suggests that pharmacological blockers of renin-angiotensin system can exert direct tissue effects independent of their ability to regulate blood pressure. The mechanism...

Liver ischemia preconditions the heart against ischemia-reperfusion arrhythmias

Objective(s):This study aimed to examine the hypothesis that an antiarrhythmic effect might be obtained by ischemic preconditioning of the liver, and also to characterize the potential underlying mechanisms. Materials and Methods: Male Wistar rats were anesthetized by thiopental sodium (50 mg/kg, IP) followed by IV injection of heparin (250 IU). Remote ischemic preconditioning (RIPC) was induce...

Diagnostic Value of Ankle Brachial Index for Myocardial Ischemia in Asymptomatic Diabetic Patients and Comparison with Myocardial Perfusion Imaging

Objective: The ankle-brachial index (ABI) as a simple test which can detect peripheral arterial disease (PAD). Therefore in this study we try to evaluate the diagnostic value of ABI for silent myocardial ischemia in diabetic patients and compare the results with myocardial perfusion imaging (MPI) results. Materials and Methods: All 149 diabetic patients in this study were categorized according...

Effects of Postconditioning, Preconditioning and Perfusion of L-carnitine During Whole Period of Ischemia/ Reperfusion on Cardiac Hemodynamic Functions and Myocardial Infarction Size in Isolated Rat Heart

Application of Anatomical and Functional Modalities in Detection of Silent Myocardial Ischemia in Asymptomatic Diabetic Patients- A Review Article

Cardiovascular disease (CAD) screening in asymptomatic patients with diabetes mellitus is controversial. An exercise stress test is a safe and effective initial testing for Ischemic Heart Disease (IHD) screening. Treadmill stress test is not the best screening method for a particular patient who is not able to exercise, abnormal electrocardiogram (ECG) or positive exercise treadmill test (ETT) ...